Chest pain, heaviness from mid chest associated with breathing difficulty or shortness of breath

Sudden visual blurriness, visual loss

Sudden severe headache, dizziness

Sudden weakness of face, or extremities, or unstable gait

Sudden numbness in the face, arms or legs

Coughing or vomiting blood

Seizures

Severe skin burns

Deep cuts or bleeding that will not stop

Intractable vomiting, severe abdominal discomfort/pain